Medley

One in four girls is depressed at age 14

Medley Depression Girls 2

New research shows a quarter of girls (24%) and one in 10 boys (9%) are depressed at age 14.

Researchers from the University of Liverpool and University College London analyzed information on more than 10,000 children born in 2000-01 who are taking part in the Millennium Cohort Study.

At ages 3, 5, 7, 11 and 14, parents reported on their children's mental health. Then, when they reached 14, the children were themselves asked questions about their depressive symptoms.

Based on the 14-year-olds reporting of their emotional problems, 24 per cent of girls and 9 per cent of boys suffer from depression.

Read more: One in four girls is depressed at age 14

New research points to better way to treat depression

Medley Depression 2 Depression

Scientists on the Florida campus of The Scripps Research Institute (TSRI) have discovered a new target for treating major depressive disorder, a disease that affects more than 16 million American adults. Their research shows that individuals with high levels of an enigmatic receptor called GPR158 may be more susceptible to depression following chronic stress.

“The next step in this process is to come up with a drug that can target this receptor”, says Kirill Martemyanov, PhD, co-chair of the TSRI Department of Neuroscience and senior author of the new study, published recently in the journal eLife.

The researchers say there is an urgent need for new drug targets in major depressive disorder. Current pharmacological treatments for depression can take a month to start working – and they don't work in all patients.

“We need to know what is happening in the brain so that we can develop more efficient therapies”, says Cesare Orlandi, PhD, senior research associate at TSRI and co-first author of the study.

The researchers zeroed in on GPR158 as a player in depression after discovering that the protein is elevated in people with major depressive disorder. To better understand GPR158's role, the scientists studied male and female mice with and without GPR158 receptors.

Read more: New research points to better way to treat depression

The Ruins of Religion

Tim Wyatt – England 

Medley The Ruins of Religion 2

Around the world millions of self-avowed religious people from every single faith tirelessly carry out good works, promote love and offer assistance to the desperate and needy. But often there is a stark disconnect between the honourable actions of these individuals and the mind-set and behaviour of the religious traditions they embrace. 

The truth is that dead letter religions increasingly make people angry. As you will note from the tone of this deliberately polemic article, I count myself among the agitated and disillusioned. And I am not alone in questioning the dark side of religious practice.

Many people find themselves caught in that No Man’s Land between atheism and religious adherence. In the West especially increasing numbers of people are choosing an alternative spiritual pathway beyond the grip of religion.

Read more: The Ruins of Religion

Impermanence

 

Medley Impermanence 2

There is no place on earth where death cannot find us – even if we constantly twist our heads about in all directions as in a dubious arid suspect land . . . If there were any way of sheltering from death's blows – I am not the man to recoil from it … But it is madness to think that you can succeed …

Read more: Impermanence

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